To sum up, the findings support CBD as a promising option for addressing learning and memory difficulties in mice with AD.
"In essence, CBD appears to alleviate synaptic dysfunction and bestow neuroprotection in Aβ1–42-induced mice," the study reads.
In Alzheimer's brains, cells gather around clumps known as amyloid plaques to clear them, but these plaques cause inflammation, damaging nerve cell connections, leading to cell death, and affecting memory.
The study examined in vitro if CBD could reduce this inflammation in mice treated with Aβ1–42. Results showed CBD significantly lowered inflammatory agents, reduced microglia activation, and lessened astrocyte activation in critical brain regions affected by Aβ-stimulation.
"Our findings suggest CBD's efficacy in moderating microglial and astrocytic activation, offering anti-inflammatory benefits that protect synaptic function and alleviate AD-associated cognitive deficits. Our data support CBD's potential therapeutic role in countering AD-related neuroinflammation," the study reads.
Moreover, CBD demonstrated its ability to restore cognitive function and enhance learning and memory impaired by Aβ in mice.
The findings highlighted CBD's effectiveness in reducing synaptic damage, neuronal loss, and the overactivation of microglia and astrocytes while simultaneously lowering neuroinflammatory markers.
"Our study has meticulously dissected the multifaceted neuroprotective and anti-inflammatory properties of CBD. We have demonstrated its capacity to counteract Aβ- induced cognitive and memory impairments, inhibit the hyperactivation of microglia and astrocytes, and augment the release of neurotrophic factors. Furthermore, our RNA-seq analyses have provided invaluable insights into CBD's role in modulating critical genes within the inflammatory cascade, underscoring its robust anti-inflammatory potential," the study concludes.
While research on CBD's impact on AD is in its early stages, promising findings have emerged. A 2021 study revealed that high doses of CBD in late-stage Alzheimer's patients increased proteins crucial for plaque removal in the brain, and a 2019 review suggests that CBD may suppress factors contributing to Alzheimer's and could be more effective in combination with THC.
